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A recent study published in the Journal Lupus by Orefice and colleagues (July 2020) compared lupus activity with average daily caffeine intake and found a definite correlation. The higher the caffeine intake the lower the activity of the lupus and the lower the dose of prednisone. There was also a suggestion that those with the highest caffeine intake had less kidney and nervous system disease, lower levels of some auto-antibodies, and decreased concentrations of some inflammatory molecules in their blood. Coffee was the major source of caffeine in these Italian lupus patients and the lowest level of caffeine intake was less than 1 cup of coffee per day. The highest was 4 or more cups/day. Although there were relatively few patients in this study and it wasn’t well controlled, the results are intriguing and warrant further study.
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About Cincinnati Rheumatic Disease Study Group

The Cincinnati Rheumatic Disease Study Group (CRDSG) is an organization of practicing rheumatologists dedicated to improving the care of patients with arthritis and other rheumatic diseases. It strives to do this by performing rigorous and ethical clinical research with the goal of developing better treatments for all patients with these conditions.
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